Fibroblasts in the cosmetic industry: advances and trends
Research into the role of fibroblasts in cosmetics, especially concerning skin regeneration, has resulted in impressive advances in aesthetic medicine. A deep understanding of these cells is revolutionizing the skincare industry in multiple ways, with an increasing number of innovative discoveries and advanced treatments that focus specifically on enhancing their action to achieve a younger and healthier appearance for many years (Zorina, et al., 2023).
Today, we will review some of the most prominent trends of fibroblasts in cosmetics, whether in their multiplication and direct application, or in other strategies to stimulate their efficacy.
What are fibroblasts and what is their role?
Fibroblasts are cells present in the dermis, the middle layer of the skin, responsible for the production of collagen, elastin, and other essential molecules that form the extracellular matrix. These cells play a leading role in tissue regeneration and repair, helping to maintain firmness and elasticity, in addition to participating in wound healing. In other words, the functions and benefits of fibroblasts in the skin are numerous.
Decades of research have enabled such advances in fibroblasts that today they can be isolated and multiplied using advanced cell culture techniques for use in aesthetic and surgical applications (Mehrabani & Manafi, 2013). The process begins with a skin biopsy, from which healthy fibroblasts are extracted and then cultured under controlled laboratory conditions to increase their potency and multiply them until millions of cells are obtained, which are subsequently reintroduced into the patient's skin to enhance collagen and elastin production, thus promoting skin rejuvenation.
Applications of fibroblasts in beauty seek to replace or stimulate lost dermal components, and have proven effective in improving sagging and wrinkles progressively and without side effects.
Why does research with fibroblasts represent a watershed moment for aesthetic medicine?
In addition to treatment with autologous fibroblasts that are reintroduced directly into the skin, other treatments focused on protecting and stimulating fibroblasts are gaining ground (Trovato, et al., 2024). Let us look at some of the advances and trends in aesthetic medicine that have been directly influenced by research with mesenchymal cells and, especially, innovations with fibroblasts.
1.- Nutraceuticals and nutricosmetics
The combination of nutrition and skincare to support fibroblast health from within is on the rise. More and more nutraceuticals and nutricosmetics are being developed and marketed, for example, collagen peptides or formulations with antioxidants such as vitamin C and E, which stimulate the production of structural proteins and protect fibroblasts from oxidative damage.
2.- Non-invasive technologies to stimulate fibroblast activity
Non-invasive technologies that stimulate fibroblasts using radiofrequencies or ultrasound are increasingly popular. These devices can reach the deep layers of the skin, activating fibroblasts and promoting collagen production without the need for surgery or recovery time.
3.- Fibroblast-derived growth factors
Fibroblast-derived growth factors (exosomes) have been used successfully in skincare (Mehta, et al., 2023). Exosomes are bioactive extracellular vesicles isolated from the secretome of human mesenchymal stem cells, which can trigger a statistically significant improvement in all skin aging parameters, including wrinkles, roughness, sagging, and laxity.
4.- Microbiome modulation to promote fibroblast activity
Recent research suggests that the skin microbiome plays a crucial role in fibroblast function. Therapies aimed at balancing the microbiome, such as probiotics and prebiotics, can optimize the skin's regenerative environment. A balanced microbiome promotes fibroblast activity, collagen production, and skin barrier function.
5.- Extracellular matrix (ECM) remodeling of the dermis
The goal of this therapy is to create favorable conditions for dermal fibroblasts through ECM remodeling. This is based on the use of medical devices, injections, and topical preparations such as retinoids, which regulate the expression of genes responsible for collagen synthesis. Laser technologies can also be used, especially ablative CO2 laser, which causes controlled thermal damage and promotes collagen production by activating a cascade of molecular and cellular mechanisms.
6.- Replacement of autologous dermal fibroblasts
Its goal is to replace fibroblasts that have decreased with age to maintain their activity. Autologous dermal fibroblasts cultured under laboratory conditions and reintroduced into the dermis via injections are used. Results include a significant increase in the number of collagen fibers, dermis thickness, and skin elasticity, with progressive effects that persist for at least two years.
Fcells: access the best autologous fibroblast treatment for your skin
You too can begin to preserve and multiply your fibroblasts at any age, and with a single annual application, you will notice significant results. At Fcells, we are the most advanced laboratory in Latin America for autologous fibroblast culture and we have a network of aesthetic doctors specialized in applying this innovative treatment, already available in Mexico.
Contact us today and we will connect you with the aesthetic medicine clinic closest to you that collaborates with our laboratories.
Related content: Fibroblasts for atopic dermatitis
REFERENCES
Mehta, R. C., Kadoya, K., Maitra, P., Goberdhan, L. T., Makino, E. T., Naughton, G. K., & Goldman, M. P. (2023). Fibroblast-derived growth factors and exosomes as cosmeceuticals. Dermatological Reviews, 4(6), 250-259. Special Issue: Cosmeceuticals - What's New & Trending- Part I.
Mehrabani, D., & Manafi, N. (2013). Role of cultured skin fibroblasts in aesthetic and plastic surgery. World journal of plastic surgery, 2(1), 2–5.
Trovato, F., Ceccarelli, S., Michelini, S., Vespasiani, G., Guida, S., Galadari, H. I., Nisticò, S. P., Colonna, L., & Pellacani, G. (2024). Advancements in regenerative medicine for aesthetic dermatology: A comprehensive review and future trends. Cosmetics, 11(2), 49.
Zorina, A., Zorin, V., Isaev, A., Kudlay, D., Vasileva, M., & Kopnin, P. (2023). Dermal Fibroblasts as the Main Target for Skin Anti-Age Correction Using a Combination of Regenerative Medicine Methods. Current issues in molecular biology, 45(5), 3829–3847.